Orthotopic Tumor Models
Tumor growth is a complex process, influenced by multiple internal and external factors. One factor that can have a significant impact is the tumor implantation site: subcutaneous or orthotopic. Subcutaneous tumors have the advantage of being easy to implant and palpable. Orthotopic tumors enable us to study the tumor in a more relevant environment providing a solution that more closely mimics the progression of human disease.
Advantages of Orthotopic Implantation:
- Provides a tumor microenvironment that recapitulates true tumor growth
- Allows for the evaluation of metastatic potential from the original tumor
- Offers the ability to track therapeutic responses
- Can be combined with imaging for in vivo and ex vivo analysis
TD2 has developed a comprehensive library of orthotopic models in mouse and human cell lines (Figure 1) at various implantation sites.
Figure 1: Site and cell lines available for orthotopic implantation.
