--- title: 4T-1-luc Syngeneic Model - TD2 Precision Oncology description: Discover 4T-1-luc, a bioluminescent mammary carcinoma cell line for imaging studies. Visualize tumor growth, metastasis, and therapy response in real-time for breast cancer research. image: https://td2inc.com/hubfs/Assets/GraphsFigures/4t-1-luc-charts.png --- ×   [![td2-logo](https://td2inc.com/hubfs/td2-logo.png "td2-logo")](https://td2inc.com/?hsLang=en) ![Search Site](https://td2inc.com/hubfs/Assets/Icon/search-icon-1.png) [![td2-logo](https://td2inc.com/hubfs/td2-logo.png "td2-logo")](https://td2inc.com/?hsLang=en) ![Search Site](https://td2inc.com/hubfs/Assets/Icon/search-icon-1.png) # 4T-1-luc Syngeneic Model **Synonyms:** 4T1 -luciferase cell line, 4T-1-luciferase-expressing cells, 4T1-luc bioluminescent cell line T-1-luc is a specialized cancer cell line derived from the 4T-1 mammary carcinoma cell line, engineered to express luciferase enzyme for imaging studies. This model allows non-invasive visualization of tumor growth and metastasis in real-time using bioluminescent imaging techniques. 4T-1-luc cells emit light that can be detected externally, enabling monitoring of tumor progression, response to treatments, and evaluation of anti-cancer therapies in preclinical studies. This cell line serves as a valuable tool for in vivo imaging and understanding the molecular mechanisms underlying breast cancer metastasis. ## Model Details **Cancer Type:** Breast Cancer **Model Name:** 4T-1-luc **Mouse Strain:** balb/c **Treatment Data Available:** aPD-1, aCTLA-4, Chemotherapy ## 4T-1-luc Growth Curves: Response to aPD-1 and aCTLA-4 ![4T-1-luc Syngeneic Model](https://td2inc.com/hubfs/Assets/GraphsFigures/4t-1-luc-charts.png) Growth of subcutaneous 4T-1-luc in balb/c mice (n=10). Response to aPD-1 dosed QoDx4 and aCTLA-4 dosced QoDx4. ### Request Additional Syngeneic Model Data ## CONTACT US ## Get Started. Have questions about how TD2 can assist with your regulatory needs? Reach out to our expert staff today to get started. [Get Started Now](https://td2inc.com/contact-us/?hsLang=en) [![td2-logo-footer](https://td2inc.com/hs-fs/hubfs/td2-logo.png?width=160&name=td2-logo.png)](https://td2inc.com/?hsLang=en) Office 13208 E. Shea Blvd, Suite 100 Scottsdale, AZ 85259 Phone (602) 358-8300 Connect with us - - ![td2-logo-footer](https://td2inc.com/hs-fs/hubfs/Assets/Logo/acclac-logo.png?width=139&name=acclac-logo.png) © 2026 Translational Drug Development. All Rights Reserved. [Terms and Conditions](https://td2inc.com/terms-and-conditions?hsLang=en) | [Privacy Policy](https://td2inc.com/privacy-policy?hsLang=en)