Immunotherapy Models

Syngeneic Mouse Tumor Models

Syngeneic mouse models enable researchers to evaluate immunotherapy candidates in a fully functional immune system. This is done by transferring a mouse tumor cell line into an inbred mouse strain with an intact immune system.

Syngeneic Models

TD2 Syngeneic models are:

  • Fully Characterized – Syngeneic tumor models are fully characterized for gene expression, TIL baseline populations, and response to common immune checkpoint inhibitors.
  • One Consistent Host — through 16S ribosomal RNA (rRNA) gene sequencing launched before the study even begins, we define the microbiome at the onset, which enables your project focused access to a known and stable host from start to finish.
  • Find Effector Cells — through multi-parameter flow cytometry, we can characterize phenotypic immune cell population changes post-treatment.

Learn more about our syngeneic services.

Contact our experts to help advance your immunotherapy candidate with our trusted preclinical research services.

Available Syngeneic Models

Figure 1. Growth curve response to standard of care treatments in orthotopic E0071 in C57BL/6 mice, subcutaneous MC38 in C57BL/6 mice, and subcutaneous CT-26 in balb/c mice in

E0771 Murine Breast Tumor Model

E0771 Murine Breast Tumor Model

MC38 Murine Colon Tumor Model

MC38 Murine Colon Tumor Model

CT-26 Murine Colon Tumor Model

CT-26 Murine Colon Tumor Model



Comprehensive preclinical services for immuno-oncology.

TD2’s extensive knowledge of CAR-T in both solid and hematologic tumors enables rapid evaluation of your CAR-T cell therapy, moving your therapeutic program forward to the clinic.

Large panel of human and murine tumor models

Cell therapy models

  • 8 years of experience in cell therapy
  • Expertise includes: CAR-T, NK-CAR, IPS-NKs, Macrophages

Humanized mice

Get Started

Work with a team who believes in your research as much as you do.

Are you ready to start your preclinical Adoptive Cell Transfer Therapy studies? Partner with a collaborative oncology CRO that believes in your treatment as much as you do. Take the first step today and contact our experts.

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