Glioblastoma Patient Derived Xenograft (PDX) Models

Glioblastoma (GBM) is the most common primary brain tumor. While many significant advances have been made understanding key genetic drivers of the disease, glioblastoma remains lethal with a 5-year survival of only 6.8%. Many factors contribute to the low survival rate- principal amongst them is a lack of relevant preclinical models. TD2 has partnered with the Mayo Clinic to offer its drug development partners access to 108 well characterized glioblastoma PDX mouse models. The PDX models recapitulate key genomic aspects of GBM including EGFR alterations, TERT promoter mutations, and CDKN2A deletions.

Features include:

  • MOA-Based Filters using selections driven by your drug’s specific mechanism of action and subsequent interrogation
  • Diverse tissue types including fixed tissue for analysis of novel markers
  • Assessment of tumor progression as single agents and in combination with standard therapies via orthotopic primary tumor models
  • Well-established protocols that ensure an extremely high post-surgery survival rate
  • Data-rich and highly characterized models with standard of care

Learn more about our Glioblastoma capabilities.

Contact our experts to help advance your Glioblastoma drug development program with our specialized models and preclinical services.

    Patient Population

    Figure 1. PDX tumor models patient characterization

    Genomic Characterization

    Figure 2. Available genomic data for PDX models (WES,
    RNAseq, Methylation

    Standard Therapy Response

    TD2 has established baseline Standard of Care (Temozolomide,
    Radiation) responses in several PDX models.

    Figure 3. Survival of orthotopic intracranial GBM 39 (EGFRvIII
    deletion) in response to Temozolomide dosed QD x 21

    Figure 4. Survival of orthotopic intracranial GBM 28 in response to radiation dosed 2Gy QD x 5 and Temozolomide dosed QD x 4 x 4.

    Summary of Key Models Available:

    For additional data on full list of models Click Here

    WES RNAseq Methylation EGFR Exon Variant PDX Treatment
    GBM5        
    GBM6       EGFRvIII  
    GBM10          
    GBM12          
    GBM14          
    GBM22          
    GBM26          
    GBM28          
    GBM38          
    GBM39       EGFRvIII  
    GBM43          
    GBM44          
    GBM46       Del. exons 13-14  
    GBM59       EGFRvIII  
    GBM64          
    GBM66          
    GBM75       EGFRvIII  
    GBM76       EGFRvIII  
    GBm79          
    GBM84          
    GBM85          
    GBM91          
    GBM102          
    GBM123       Del. exons 13-14  
    GBM129          
    GBM134          
    GBM148          
    GBM150          
    GBM196          

    Comprehensive
    Preclinical Services

    Regardless of the development question, TD2 has the specialized model you need to move your drug forward. Clients have access to humanized models, induction models, as well as specialty surgical and orthotopic models. We specialize in all areas of oncology and work diligently to understand your therapeutics’ mechanism of action. We match that with clinical development strategies for an efficient path forward.

    Get Started

    Work with a team who believes in your research as much as you do.

    Are you ready to start your preclinical Glioblastoma studies? Partner with a collaborative oncology CRO that believes in your treatment as much as you do. Take the first step today and contact our experts.