--- title: Caki-1 CDX Model - TD2 Precision Oncology description: Caki-1 is a metastatic renal cell carcinoma cell line, instrumental for studying the advanced stages of RCC and for evaluating therapeutic interventions against metastasis. image: https://td2inc.com/hubfs/Assets/GraphsFigures/Caki-1.png --- ×   [![td2-logo](https://td2inc.com/hubfs/td2-logo.png "td2-logo")](https://td2inc.com/?hsLang=en) ![Search Site](https://td2inc.com/hubfs/Assets/Icon/search-icon-1.png) [![td2-logo](https://td2inc.com/hubfs/td2-logo.png "td2-logo")](https://td2inc.com/?hsLang=en) ![Search Site](https://td2inc.com/hubfs/Assets/Icon/search-icon-1.png) # Caki-1 CDX Model The Caki-1 cell line is derived from human renal cell carcinoma (RCC), specifically from the metastatic site of the disease in the skin. This origin provides Caki-1 with a unique perspective on the aggressive and metastatic behaviors of RCC. Caki-1 is a crucial model for delving into the pathogenesis of metastatic RCC and for gauging therapeutic interventions’ effectiveness. It mirrors several molecular features and genetic alterations seen in RCC patients, especially those with advanced stages, making it a pivotal model for preclinical studies. The in vitro and in vivo behaviors of Caki-1 offer insights into RCC’s growth kinetics, invasive properties, angiogenesis, and potential therapeutic responses. Researchers often employ the Caki-1 model to uncover the molecular mechanisms driving RCC metastasis and to test and fine-tune innovative therapeutic strategies, particularly those aimed at halting or reversing metastatic progression. ## Model Details **Cancer Location:** Kidney **Cancer Type:** Renal Cell Carcinoma **Model Name:** Caki-1 **Mouse Strain:** NSG ## Caki-1 Growth curves ![Caki-1 CDX Model](https://td2inc.com/hubfs/Assets/GraphsFigures/Caki-1.png) Growth of subcutaneous Caki-1 in NSG mice (n=5) ### Request Additional CDX Model Data ## CONTACT US ## Get Started. Have questions about how TD2 can assist with your regulatory needs? Reach out to our expert staff today to get started. [Get Started Now](https://td2inc.com/contact-us/?hsLang=en) [![td2-logo-footer](https://td2inc.com/hs-fs/hubfs/td2-logo.png?width=160&name=td2-logo.png)](https://td2inc.com/?hsLang=en) Office 13208 E. Shea Blvd, Suite 100 Scottsdale, AZ 85259 Phone (602) 358-8300 Connect with us - - ![td2-logo-footer](https://td2inc.com/hs-fs/hubfs/Assets/Logo/acclac-logo.png?width=139&name=acclac-logo.png) © 2026 Translational Drug Development. All Rights Reserved. [Terms and Conditions](https://td2inc.com/terms-and-conditions?hsLang=en) | [Privacy Policy](https://td2inc.com/privacy-policy?hsLang=en)