Orthotopic vs. Subcutaneous: Unpacking the Strengths and Limitations of Tumor Model Implantation Sites

The scientific community has long appreciated the importance of in vivo tumor models for understanding cancer biology and testing therapeutic strategies. Two popular methods for tumor implantation in these models are orthotopic and subcutaneous implantation. Both have their advantages, and the choice often depends on the specific goals of a study. In this post, we'll delve deep into the benefits of each method to guide researchers in their decision-making process.