Immunotherapy and cell therapy have revolutionized the field of cancer treatment by harnessing the power of the immune system to fight cancer cells. However, the development of effective immunotherapy drugs such as immune checkpoint inhibitors requires extensive preclinical testing to ensure safety and efficacy. Breakthroughs in the field are faced with several challenges including the generation of appropriate humanized mouse models for preclinical evaluation. Among others, genetically-engineered mouse models have emerged as valuable tools for improving cancer treatment outcomes.
July 13, 2023
- A Translational Lens on Synergistic Cancer Therapy: Insights from Our Recent Case Study
- Redesigning Preclinical Oncology: A Framework for Improving Clinical Translatability with AI, RECIST-Inspired Metrics, and Systems-Level Thinking
- Radiopharmaceutical Dosing Under FDA’s New Spotlight: What You Should Know
- Expanding Access to CART Therapies: TD2 Oncology Featured in SCRS inFocus
- The Rise of Humanized Mouse Models in Oncology: What Drug Developers Need to Know
A Translational Lens on Synergistic Cancer Therapy: Insights from Our Recent Case Study
In cancer drug development, monotherapies often lose ground when tumors adapt. This is especially true for KRASmutant non–small cell lung cancers ...
Redesigning Preclinical Oncology: A Framework for Improving Clinical Translatability with AI, RECIST-Inspired Metrics, and Systems-Level Thinking
Despite decades of investment in oncology drug development, the translational pipeline from preclinical models to clinical success remains ...
Radiopharmaceutical Dosing Under FDA’s New Spotlight: What You Should Know
The FDA has issued a new draft guidance titled “Oncology Therapeutic Radiopharmaceuticals: Dosage Optimization During Clinical Development.” This ...
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