Immunotherapy and cell therapy have revolutionized the field of cancer treatment by harnessing the power of the immune system to fight cancer cells. However, the development of effective immunotherapy drugs such as immune checkpoint inhibitors requires extensive preclinical testing to ensure safety and efficacy. Breakthroughs in the field are faced with several challenges including the generation of appropriate humanized mouse models for preclinical evaluation. Among others, genetically-engineered mouse models have emerged as valuable tools for improving cancer treatment outcomes.
July 13, 2023
- Model Spotlight: Breast Cancer Clinical Update and Preclinical Plan
- Advancing Preclinical Research in Gynecologic Cancers
- History of CAR T-cells and Their Continued Use in Hematological Malignancies to Advance Next-Generation Therapies
- Cancer Support: Contract Research Organizations, More Than a Vendor, a Partner In Drug Development.
- Advancing Bone and Sarcoma Cancer Research Through Robust In Vivo Models
Model Spotlight: Breast Cancer Clinical Update and Preclinical Plan
Based on the American Cancer Society 2026 estimates and survival statistics, as of October 2026, developments in antibody-drug conjugates (ADCs), ...
Advancing Preclinical Research in Gynecologic Cancers
Gynecologic cancers, including endometrial and ovarian cancers, remain areas of high unmet need. Advances in targeted therapy, immunotherapy, ...
History of CAR T-cells and Their Continued Use in Hematological Malignancies to Advance Next-Generation Therapies
CAR T-cell therapy originated in the late 1980s, first-generation constructs lacked adequate co-stimulatory signaling, causing poor CAR T-cell ...
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