HuT78 CDX Model
The HuT78 cell line is derived from human cutaneous T cell lymphoma (CTCL), a subset of non-Hodgkin lymphomas characterized by malignant T lymphocytes primarily involving the skin. CTCL presents various subtypes, with HuT78 offering a crucial platform for exploring the disease’s complex biology, pathogenesis, and potential therapeutic windows. This cell line embodies the defining molecular signatures and genetic mutations frequently associated with CTCL, accentuating its role in preclinical research. HuT78’s behavior in vitro and in vivo provides insights into CTCL’s unique growth patterns, skin microenvironment interactions, and systemic manifestations. Researchers often employ the HuT78 model to probe the molecular dynamics of CTCL, the intricate interplay between tumor cells and the skin immune milieu, and to evaluate the efficacy of both topical and systemic therapeutic modalities. The HuT78 cell line is foundational for devising targeted and immune-based treatments for CTCL.
Model Details
Cancer Location: Intradermal
Cancer Type: Cutaneous T Cell Lymphoma
Model Name: HuT78
Mouse Strain: NSG
HuT 78 Growth Curves
Growth of subcutaneous HuT 78 in NSG mice (n=10 mice)
