Diet Induced Obesity Model for Cancer Research

A More Clinically Relevant Model to Uncover Your Treatment’s Potential

Obesity is a risk factor for at least 13 different forms of cancer. Mechanisms in which obesity and changes in systemic metabolism affect the tumor microenvironment (TME) and impact antitumor immunity are unclear. Current preclinical models use mouse strains which are fed a controlled diet and therefore host mice are not representative of Western human cancer populations. TD2 has established a diet induced obesity tumor model (Figure 1) to screen cancer therapies in a more clinically relevant system.

Figure 1: Establishment of diet induced obesity mouse tumor model

Benefits of Diet Induced Obesity Mouse Models:

  • Execute studies in more clinically relevant models reflective of the significant rates of obesity projected by 2035.
  • Understand how obesity induced systemic changes in metabolism effect the tumor microenvironment
  • Identify new treatments/mechanism of action that may show increased therapeutic benefit in DIO models
  • Quantify metabolite and proteomic changes in response to treatment that could be used as biomarkers of treatment benefit or as opportunity for new targets for drug development

Figure 2: Growth of subcutaneous MC38 model in C57BL6 mice (n=10) and
evaluation of anti-PD1 in DIO mice versus age matched Controlled Diet (CD) mice dosed Q3D x 4

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Diet Induced Obesity Model Impact on ICI Treatment

Diet Induced Obesity Model
Impact on ICI Treatment

One of the major benefits of using diet-induced obesity (DIO) in mouse models for cancer research is that the diet-induced obesity itself can be manipulated to study how this condition can modulate cancer progression. DIO mouse models can help us further elucidate the mechanisms underlying these cancers. Additionally, DIO mouse models can be used to investigate the bi-directional relationship between obesity and cancer including direct tumor growth and the effects of obesity on cancer therapies.

Significant metabolite alterations between treated
and untreated DIO and CD mice

    DIO mouse models offer the potential to study how diet-induced obesity can modulate the effects of different cancer treatments. It is believed that changes in metabolic factors, such as glucose and fatty acid metabolism, as well as other hormones, may influence the efficacy of treatments. DIO mouse models can help to elucidate these changes, aiding the development of targeted therapies for patients.

  • DIO mice showed stronger metabolic response to amPD-1
  • Very little similarity between treatment groups
  • Multiple metabolites showed differential response in DIO vs CD

Comprehensive Preclinical Services

Comprehensive
Preclinical Services

Regardless of the development question, TD2 has the specialized model you need to move your drug forward. Clients have access to humanized models, induction models, as well as specialty surgical and orthotopic models. We specialize in all areas of oncology and work diligently to understand your therapeutics’ mechanism of action. We match that with clinical development strategies for an efficient path forward.

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