U251 Orthotopic Model
U251 is a well-established human glioblastoma cell line that serves as a valuable model for studying glioblastoma multiforme (GBM), a highly aggressive brain cancer. It exhibits key features and genetic alterations observed in GBM patients, making it an essential tool for preclinical research. U251 closely mimics GBM characteristics, including invasive growth, angiogenesis, and resistance to treatments. Researchers utilize U251 to gain insights into GBM biology, evaluate therapeutic strategies, and develop novel treatment approaches.
Cancer Type: Brain Cancer
Model Name: U251
Mouse Strain: Nu/Nu
Treatment Data Available: Chemotherapy (Temolozide)
Survival of U251 after orthotopic intracranial injection in Nu/Nu mice (n=10)