---
title: TC-1 Syngeneic Model - TD2 Precision Oncology
description: Explore TC-1, a versatile lung cancer cell line with HPV transformation, valuable for studying tumor progression and immune response in preclinical research.
image: https://td2inc.com/hubfs/Assets/GraphsFigures/tc-1.png
---
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# TC-1 Syngeneic Model
**Synonyms:** TC1, TC1 cells, TC-1 lung cancer cell line
TC-1 is a well-established cancer cell line derived from lung epithelial cells that have been transformed with oncogenic human papillomavirus (HPV) E6 and E7 genes. TC-1 cells are commonly used in preclinical studies of lung cancer and HPV-associated tumors. They exhibit aggressive tumorigenic behavior and provide a valuable model for investigating tumor progression, immune response, and evaluating potential therapies. TC-1 is particularly useful for studying the impact of HPV on lung cancer development and exploring immunotherapeutic interventions.
## Model Details
**Cancer Type:** Lung Cancer
**Model Name:** TC-1
**Mouse Strain:** C57BL/6
**Treatment Data Available:** aPD-1, aCTLA-4, Chemotherapy
## TC-1 Growth Curve: Response to Cisplatin
Growth of subcutaneous TC-1 in C57BL/6 mice (n=10). Response to Cisplatin dosed QWx3
### Request Additional Syngeneic Model Data
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