SKOV-3 CDX Model 

The SKOV-3 cell line is derived from human ovarian adenocarcinoma, a form of ovarian cancer that arises from the epithelial cells lining the ovary. Ovarian cancer is known for its late diagnosis and significant therapeutic challenges, given its often-silent progression. SKOV-3 offers an invaluable tool for investigating the biology, progression, and treatment strategies associated with ovarian adenocarcinoma. With a unique genetic and molecular profile that reflects certain characteristics of ovarian cancer patients, SKOV-3 is of great relevance for preclinical investigations. The in vitro and in vivo behavior of SKOV-3 grants insights into tumor growth dynamics, invasive tendencies, and drug sensitivities typical of ovarian tumors. The SKOV-3 model is extensively used by researchers to understand the complex molecular landscape of ovarian cancer, to test the potency of novel therapeutic agents, and to discern potential mechanisms of resistance to frontline treatments.

Model Details

Cancer Location: Ovarian
Cancer Type: Ovarian Cancer
Model Name: SKOV-3
Mouse Strain: NSG, Nu/Nu
Treatment Data Available: Chemotherapy (Herceptin, Copanlisib)

SK-OV-3 Growth curves

Growth of subcutaneous SK-OV-3 in NSG mice (n=10)

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