NCI-N87 CDX Model

The NCI-N87 cell line originates from human gastric cancer, a malignancy that arises from the lining of the stomach. Gastric cancer is known for its varied histological subtypes and its potential for metastasis, particularly to the peritoneum, liver, and lungs. The NCI-N87 cell line provides a comprehensive platform for exploring the intricate biology, progression, and therapeutic challenges associated with stomach cancer. Representing distinct molecular features and genetic mutations commonly identified in gastric cancer patients, NCI-N87 plays a pivotal role in preclinical studies. The in vitro and in vivo behavior of NCI-N87 offers valuable insights into the growth kinetics, invasive tendencies, and therapeutic responsiveness of gastric tumors. Researchers extensively utilize the NCI-N87 model to study the molecular dynamics of stomach cancer, to assess the impact of novel therapeutic interventions, and to discern potential mechanisms of resistance to established treatments.

Model Details

Cancer Location: Stomach
Cancer Type: Gastric Cancer
Model Name: NCI-N87
Mouse Strain: Athymic Nude
Treatment Data Available: Chemotherapy (Herceptin, 5-FU)

NCI-N87 Growth curves

NCI-N87 CDX Model

Growth of subcutaneous NCI-N87 in Athymic Nude mice (n=5)

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