MOPC-315 Syngeneic Model
Synonyms: MOPC315, Plasmacytoma cell line
MOPC-315 is a widely used cancer cell line derived from a murine plasmacytoma. It serves as a valuable tool in cancer research, particularly in the study of plasma cell malignancies and immunotherapy. MOPC-315 cells exhibit characteristics resembling plasma cells and are employed to investigate tumor biology, immunological responses, and therapeutic interventions. Researchers utilize MOPC-315 to explore genetic alterations, signaling pathways, immune checkpoint regulation, and drug sensitivity. The cell line is frequently used in preclinical models to evaluate the efficacy of immunotherapeutic strategies, including monoclonal antibodies and immune checkpoint inhibitors. MOPC-315 contributes to advancing our understanding of plasma cell malignancies and developing innovative immunotherapies for cancer treatment.
Cancer Type: Hematopoietic Cancer
Model Name: MOPC-315
Mouse Strain: BALB/C
Treatment Data Available: N/A
Survival of MOPC-315 in IV disseminated models in balb/c mice (n=5) . Group 1: 5 x 106 cells/mouse + 450 cGy . Group 2: 1 x 107 cells/mouse + 450 cGy.