HH CDX Model
The HH cell line is derived from human cutaneous T cell lymphoma (CTCL), a group of non-Hodgkin lymphomas that primarily affect the skin. CTCL encompasses various subtypes, with the HH cell line offering valuable insights into the disease’s complex pathogenesis and potential therapeutic avenues. This cell line showcases the hallmark molecular features and genetic mutations commonly associated with CTCL, reinforcing its importance in preclinical investigations. The in vitro and in vivo behavior of HH provides a comprehensive understanding of CTCL’s growth patterns, its interaction with the skin microenvironment, and potential systemic involvements. Researchers extensively use the HH model to explore the intricacies of CTCL pathogenesis, the tumor-immune cell interactions in the skin, and to assess the efficacy of both topical and systemic therapeutic agents. The HH cell line acts as a foundation for developing targeted therapies and immune-based interventions tailored for CTCL.
Cancer Location: Intradermal
Cancer Type: Cutaneous T Cell Lymphoma
Model Name: HH
Mouse Strain: NSG
HH Growth Curves
Growth of subcutaneous HH in NSG mice (n=5 mice)