---
title: CCRF-CEM CDX Model - TD2 Precision Oncology
description: CCRF-CEM is a prominent cell line used to study acute T cell lymphoblastic leukemia, aiding in the understanding of its biology and in the assessment of therapeutic responses.
image: https://td2inc.com/hubfs/Assets/GraphsFigures/CCRF-CEM.jpg
---
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# CCRF-CEM CDX Model
**Synonyms:** CEM
The CCRF-CEM cell line originates from human acute T cell lymphoblastic leukemia (T-ALL), a subtype of acute lymphoblastic leukemia that arises from T cell precursors. CCRF-CEM provides a valuable in vitro and in vivo model for understanding the biology, pathogenesis, and therapeutic responses of T-ALL. Exhibiting key molecular characteristics and genetic features of T-ALL, the CCRF-CEM cell line serves as a representative model for preclinical investigations related to this aggressive leukemia. Its behavior closely mimics the rapid proliferative nature of T-ALL, along with its interactions with the bone marrow microenvironment and potential for systemic dissemination. Researchers frequently utilize CCRF-CEM to gain deeper insights into T-ALL pathogenesis, the leukemia-stroma interactions, and to test and develop new therapeutic regimens, particularly those related to targeted and chemotherapeutic interventions.
## Model Details
**Cancer Location:** Intravenous
**Cancer Type:** Acute T Cell Lymphoblastic Leukemia
**Model Name:** CCRF-CEM
**Mouse Strain:** NSG, CB.17 SCID
## CCRF-CEM Growth Curves
Growth of subcutaneous CCRF-CEM in NSG mice (n=5)
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