A2780 CDX Model
The A2780 cell line is derived from human ovarian cancer, representing a non-mucinous endometrioid phenotype. It is an indispensable tool for studying ovarian cancer pathogenesis and for evaluating therapeutic interventions. A2780 is particularly notable for its sensitivity to cisplatin, making it a benchmark model for assessing chemotherapeutic responses. Furthermore, A2780 exhibits key molecular and genetic features commonly observed in ovarian cancer patients, which provides a representative platform for preclinical investigations. Its in vitro and in vivo behavior accurately portrays the characteristics of ovarian cancer, such as tumor growth, dissemination patterns within the peritoneal cavity, and response to frontline treatments. Researchers employ A2780 to enhance their understanding of ovarian cancer biology and to test and develop innovative treatment strategies, especially those related to chemoresistance mechanisms.
Model Details
Cancer Location: Ovary
Cancer Type: Ovarian Cancer
Model Name: A2780
Mouse Strain: Nu/Nu
Treatment Data Available: Chemotherapy (Paclitaxel, Cisplatin, Docetaxel)
A2780 Growth curves
Growth of subcutaneous A2780 in Nu/Nu mice (n=5)
