4T-1 Syngeneic Model

Synonyms: 4T1 mammary carcinoma cell line, 4T1 breast cancer cell line

4T-1 is a well-established cancer cell line derived from a murine mammary tumor. It is widely used in breast cancer research, providing valuable insights into tumor growth, metastasis, and therapeutic interventions. The cells exhibit characteristics similar to human breast cancer, making them suitable for studying the disease. 4T-1 cells have an epithelial morphology and can form tumors when implanted in animal models. Researchers utilize 4T-1 to investigate various aspects of breast cancer, including genetic alterations, signaling pathways, immune responses, and drug sensitivity. It has been extensively employed in preclinical models to evaluate the efficacy of different treatment approaches, such as chemotherapy, targeted therapies, immunotherapy, and combination treatments. The 4T-1 cell line plays a crucial role in advancing our understanding of breast cancer and developing novel strategies for its diagnosis and treatment.

Model Details

Cancer Type: Breast Cancer
Model Name: 4T-1
Mouse Strain: balb/c
Treatment Data Available: aPD-1, Chemotherapy

4T-1 Growth Curves: Response to aPD-1

Growth of orthotopic 4T-1 in balb/c mice (n=10). Response to aPD-1 dosed Q3Dx4.