4T-1-luc Syngeneic Model

Synonyms: 4T1 -luciferase cell line, 4T-1-luciferase-expressing cells, 4T1-luc bioluminescent cell line

T-1-luc is a specialized cancer cell line derived from the 4T-1 mammary carcinoma cell line, engineered to express luciferase enzyme for imaging studies. This model allows non-invasive visualization of tumor growth and metastasis in real-time using bioluminescent imaging techniques. 4T-1-luc cells emit light that can be detected externally, enabling monitoring of tumor progression, response to treatments, and evaluation of anti-cancer therapies in preclinical studies. This cell line serves as a valuable tool for in vivo imaging and understanding the molecular mechanisms underlying breast cancer metastasis.

Model Details

Cancer Type: Breast Cancer
Model Name: 4T-1-luc
Mouse Strain: balb/c
Treatment Data Available: aPD-1, aCTLA-4, Chemotherapy

4T-1-luc Growth Curves: Response to aPD-1 and aCTLA-4

Growth of subcutaneous 4T-1-luc in balb/c mice (n=10). Response to aPD-1 dosed QoDx4 and aCTLA-4 dosced QoDx4.