4T-1-luc Syngeneic Model

Synonyms: 4T1 -luciferase cell line, 4T-1-luciferase-expressing cells, 4T1-luc bioluminescent cell line

T-1-luc is a specialized cancer cell line derived from the 4T-1 mammary carcinoma cell line, engineered to express luciferase enzyme for imaging studies. This model allows non-invasive visualization of tumor growth and metastasis in real-time using bioluminescent imaging techniques. 4T-1-luc cells emit light that can be detected externally, enabling monitoring of tumor progression, response to treatments, and evaluation of anti-cancer therapies in preclinical studies. This cell line serves as a valuable tool for in vivo imaging and understanding the molecular mechanisms underlying breast cancer metastasis.

Model Details

Cancer Type: Breast Cancer
Model Name: 4T-1-luc
Mouse Strain: balb/c
Treatment Data Available: aPD-1, aCTLA-4, Chemotherapy

4T-1-luc Growth Curves: Response to aPD-1 and aCTLA-4

Growth of subcutaneous 4T-1-luc in balb/c mice (n=10). Response to aPD-1 dosed QoDx4 and aCTLA-4 dosced QoDx4.

Request Additional Syngeneic Model Data

Contact Us

Get Started.

Have questions about how TD2 can assist with your regulatory needs? Reach out to our
expert staff today to get started.

Skip to content