U87-MG Orthotopic Model
U87-MG is a well-established cell line derived from human glioblastoma multiforme (GBM). It is widely utilized in research to investigate GBM biology, therapeutic responses, and potential treatment targets. U87-MG exhibits characteristic features of GBM, including invasiveness, angiogenesis, and resistance to therapies. Researchers employ this model to explore molecular pathways involved in GBM progression, develop novel therapeutics, and evaluate drug efficacy in preclinical settings. The availability of genetic and genomic information further enhances the utility of U87-MG for understanding GBM heterogeneity and personalized medicine approaches.
Cancer Type: Brain Cancer
Model Name: U87-MG
Mouse Strain: Nu/Nu
Treatment Data Available: Chemotherapy (Temodar, Lomustine)
Survival of U87-MG after orthotopic intracranial injection in Nu/Nu mice (n=10)