TC-1 Syngeneic Model

Synonyms: TC1, TC1 cells, TC-1 lung cancer cell line

TC-1 is a well-established cancer cell line derived from lung epithelial cells that have been transformed with oncogenic human papillomavirus (HPV) E6 and E7 genes. TC-1 cells are commonly used in preclinical studies of lung cancer and HPV-associated tumors. They exhibit aggressive tumorigenic behavior and provide a valuable model for investigating tumor progression, immune response, and evaluating potential therapies. TC-1 is particularly useful for studying the impact of HPV on lung cancer development and exploring immunotherapeutic interventions.

Model Details

Cancer Type: Lung Cancer
Model Name: TC-1
Mouse Strain: C57BL/6
Treatment Data Available: aPD-1, aCTLA-4, Chemotherapy

TC-1 Growth Curve: Response to Cisplatin

Growth of subcutaneous TC-1 in C57BL/6 mice (n=10). Response to Cisplatin dosed QWx3