Humanized Mouse Models for Immune Checkpoint Inhibitors
Evaluate your human specific immunotherapy in vivo
Humanized checkpoint inhibitor mice provide a unique opportunity to study the effect of human specific immunotherapies in vivo. By genetically engineering the mouse models to have human immune targets, these models are able to provide a higher degree of accuracy in terms of predicting drug efficacy. Compared to other animal models, humanized checkpoint inhibitor mice are ideal for testing the effect of your treatment candidate because they can respond to immunotherapy treatments in the same way humans do.
Benefits of using humanized immune checkpoint inhibitors for I/O research
- Enable the evaluation of human-specific biological therapies in vivo faster than traditional animal models
- Double and triple KI models
- Lack of expression of the murine target gene, avoiding cross-reactivity
- Provides a more predictive model for how drugs will perform in the clinic
