In the sphere of immuno-oncology research, a powerful tool has emerged - the Diet-Induced Obesity (DIO) mouse model. These models provide researchers a practical route to understanding the connections between obesity, immunity, and cancer treatment. The real value of DIO mice lies in their ability to reflect human-like responses, marking a new phase of discovery. Below are the top 5 reasons researchers should be incorporating DIO mice into the preclinical evaluation of immuno-oncology treatments.