RPMI-8226 CDX Model
The RPMI-8226 cell line is derived from human multiple myeloma, a cancer of plasma cells that primarily affects the bone marrow. Multiple myeloma is marked by its production of abnormal antibodies and its potential to cause bone lesions, anemia, and kidney dysfunction. The RPMI-8226 cell line serves as a robust platform for studying the complex biology, progression, and therapeutic challenges associated with multiple myeloma. Featuring distinct molecular features and genetic markers typically found in myeloma patients, RPMI-8226 is of paramount importance in preclinical studies. Its in vitro and in vivo behavior provides crucial insights into tumor growth dynamics, interaction with the bone marrow microenvironment, and response to therapeutic agents. Researchers leverage the RPMI-8226 model extensively to delve into the molecular and cellular dynamics of multiple myeloma, assess the efficacy of novel therapeutic compounds, and investigate potential resistance pathways to standard treatments.
Model Details
Cancer Location: Bone Marrow
Cancer Type: Multiple Myeloma
Model Name: RPMI-8226
Mouse Strain: NOD SCID, NSG
Treatment Data Available: Chemotherapy (Bortezomib, Velcade)
RPMI-8226 Growth Curves
Growth of subcutaneous RPMI-8226 in NOD SCID mice (n=10 mice)
