---
title: Nalm-6 CDX Model - TD2 Precision Oncology
description: Nalm-6 serves as an essential cell line for acute lymphoblastic leukemia research, providing insights into the disease's cellular dynamics and aiding in the development and evaluation of therapeutic strategies.
image: https://td2inc.com/hubfs/Assets/GraphsFigures/Nalm-6.png
---
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# Nalm-6 CDX Model
**Synonyms:** OCI-AML-2
The Nalm-6 cell line is derived from human acute lymphoblastic leukemia (ALL), a malignancy characterized by an overproduction of immature white blood cells in the bone marrow. ALL is known for its rapid progression and its predilection for infiltrating the bone marrow, thus displacing healthy cells. The Nalm-6 cell line offers a comprehensive platform for understanding the underlying molecular mechanisms, progression, and potential therapeutic avenues of ALL. Representing key molecular and genetic traits common in ALL patients, Nalm-6 stands as an instrumental model for preclinical studies. The in vitro and in vivo behavior of Nalm-6 provides valuable insights into the growth dynamics of leukemia cells, their interaction with the bone marrow environment, and their response to various therapeutic agents. Researchers extensively use Nalm-6 to delve into the pathogenesis of ALL, evaluate the efficacy of novel treatments, and to gain insights into potential mechanisms of drug resistance in leukemia.
## Model Details
**Cancer Location:** Intravenous
**Cancer Type:** Acute Lymphoblastic Leukemia
**Model Name:** Nalm-6
**Mouse Strain:** Nu/J
**Treatment Data Available:** Chemotherapy (Venetoclax, 5-Aza)
## OCI-AML-2 Growth Curves
Growth of subcutaneous OCI-AML-2 in Nu/J mice (n=10)
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