---
title: MC38 Syngeneic Model - TD2 Precision Oncology
description: Discover MC38, a murine colon adenocarcinoma cell line used in colorectal cancer research. Study tumor biology, therapeutic interventions, and immune responses.
image: https://td2inc.com/hubfs/Assets/GraphsFigures/mc38.png
---
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# MC38 Syngeneic Model
**Synonyms:** MC-38, MC38 colon tumor cell line
MC38 is a widely studied cancer cell line derived from a murine colon adenocarcinoma. It serves as an important model in colorectal cancer research, providing insights into tumor biology, therapeutic interventions, and immune responses. MC38 cells exhibit characteristics similar to human colon adenocarcinoma, making them valuable for studying the disease. They have an epithelial morphology and are capable of forming tumors when implanted in animal models. Researchers utilize MC38 to investigate genetic alterations, signaling pathways, immune checkpoint regulation, and drug sensitivity in colorectal cancer. It has been extensively employed to evaluate the efficacy of various treatment approaches, including chemotherapy, immunotherapy, and combination therapies. The MC38 cell line plays a significant role in advancing our understanding of colorectal cancer and developing novel strategies for its diagnosis and treatment.
## Model Details
**Cancer Type:** Colorectal Cancer
**Model Name:** MC38
**Mouse Strain:** C57BL/6
**Treatment Data Available:** aPD-1, aCTLA-4, aCD-40
## MC38 Growth Curves: Response to aPD-1 and CD-40
Growth of subcutaneous MC38 in C57BL/6 mice (n=10). Response to aPD-1 dosed BIW and aCD-40 dosed BIW.
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