---
title: HCT116 CDX Model - TD2 Precision Oncology
description: HCT116 is a seminal cell line for studying colorectal cancer, particularly those tumors with microsatellite instability, aiding in drug development and therapeutic research.
image: https://td2inc.com/hubfs/Assets/GraphsFigures/hct116.jpg
---
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# HCT116 CDX Model
The HCT116 cell line is derived from human colorectal cancer (CRC), one of the most common malignancies globally. This cell line serves as a cornerstone in studying the biology, pathogenesis, and therapeutic responses of CRC. It is especially known for its microsatellite instability (MSI), a distinct genetic trait that results from defects in the DNA mismatch repair system, making HCT116 particularly relevant for research into this subset of colorectal tumors. HCT116 exhibits many molecular features and genetic mutations typically seen in CRC patients, making it a highly representative model for preclinical studies. The in vitro and in vivo behavior of HCT116 provides a window into the growth dynamics, invasive properties, and potential metastatic tendencies of CRC. Researchers widely use HCT116 to dissect molecular pathways in CRC, test drug responses, especially in MSI-high tumors, and to develop novel therapeutic approaches targeting CRC’s unique vulnerabilities.
## Model Details
**Cancer Location:** Colon
**Cancer Type:** Colorectal Cancer
**Model Name:** HCT116
**Mouse Strain:** NOD-SCID
**Treatment Data Available:** Chemotherapy (Irinotecan, Avastin)
## HCT-116 Growth curves
Growth of subcutaneous HCT-116 in NOD-SCID mice (n=8 mice).
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